charlie liu,
qualifications:
1. md, phd, shanghai medical university
2. 10 years ’ working experience in icu, internal medicine, hematology department
3. 10 more years us working experience (postdoc, senior scientis in top us university medical schools) with excellent written and spoken english;
4. highly skilled in project managenent
5. responsible and customer-oriented;
6. overseas degree and working experience are highly preferred.
上海医科大学医学博士,美国印第安那大学博士后,长期从事急症医学,内科学,血液肿瘤学, 感染临床与免疫研究。 2000 年获得美国免疫学会特殊博士后基金。之前曾获中国卫生部青年研究基金。 在国内外一级期刊发表论文逾 30 篇, 拥有欧洲,美国, 中国四项专利涉及基因与蛋白药物及新的诊断技术。现在美国与数位资深科学家合*******公司, 专业从事生物医学新技术新药物的研究与开发, 尤其侧重于采用免疫与分子技术对感染性疾病的诊断与治疗研究。
与合作伙伴的专利“一种快速检测结核菌感染及药物敏感性的生物免疫学技术”结合了噬菌体扩增技术和免疫放大技术,克服了传统技术敏感性低、检测时间长、假阳性假阴性率高等缺点,可在 24 小时内作出快速检测。与现有技术相比,本技术可明显提高检测敏感性、特异性、生物安全性等性能,而且能准确提示患者体内是否有活动性结核菌。如果该患者已接受抗结核治疗, 检测结果可以帮助判断结核菌对药物治疗的敏感性。 如果在实验痰样品的制备步骤中加入抗结核药物, 结果尚可帮助体外筛选抗结核治疗的敏感药物。因此,该技术是结核病细菌学检测及治疗方面的一项大突破。
简历:
****** *982.9-1985.7
上海医科大学 1988.9-1991.7 医学硕士
上海医科大学 1991.9-1994.7 医学博士
德国 daad 奖学金, tubingen 大学访问学者 1995.12-1987.12
美国印第安纳大学博士后, 1998.12-2001.4
美国 seattle 传染病研究所资深科学家, 2001.5-2003.4
美国华盛顿大学资深科学家, hiv 疫苗开发与转基因小鼠的建立, 2003.4- 至今
美国 biogate international **公司, 执行总裁
2004-present : ceo , biogate international , seattle , wa 98155 , usa
2003-prresent : senior scientist , hiv vaccine and transgenic mice development, university of washington , usa
2001-2003 : scientist , infectionus disease res. institute , tb antigen cloning and discover seattle , wa , usa
1997-2001 : postdoc , indiana university , usa
1995-1997 : visiting schalor , university of tuebingen , germany
1988-1995 :上海医科大学, 硕士生, 博士生
honors
patent: tubingen university , germany 1997 “ reversal effect of pkc antisense on mdr cancer cells”
patent: indian university 2001 “a novel family of four human innate immunity pattern recognition molecules”
patent: university of washington 2004 “gene mutations in circulating community herpes simplex virus type 2 strains: implications for vaccine design”
immune deficiency foundation (usa , $25,000, 1999-2000)
young investigator grant from chinese health ministry (1992-1994, 15,000 rmb)
overseas research students (ors) fellowship from university of london (1996, $8,000)
deutsche academic research fellowship, 1996 from bonn , germany (30,000 dm)
fellowship from byk gulden gmbh, konstanz , germany ,40,000dm
publications
lichun dong, charlie liu , william muller, adrian vilalta, benjamin byrd, michal margalith, andrew geall, and david m. koelle
cellular and humoral immune responses to hsv-2 tegument proteins in h-2d mice after dna vaccination. j. immunology 2009 in press
charlie liu, anna wald, rhoda ashley-morrow, lawrence corey, david m. koelle. sequences of cd8 t-cell antigens in circulating community herpes simplex virus type 2 strains: implications for vaccine design. j virology in preparation 2009
czartoski t , liu c , koelle dm , schmechel s , kalus a , wald a . fulminant, acyclovir-resistant, herpes simplex virus type 2 hepatitis in an immunocompetent woman. j clin microbiol. 2006 apr; 44 (4):1584-6.
liu, c., flamoe, e., chen, h.j., and campos-neto, a. (2004) expression and purification of immunologically reactive dppd, a recombinant mycobacterium tuberculosis skin test antigen, using mycobacterium smegmatis and escherichia coli host cells. can. j. microbiol. 50: 97-105.
mukherjee s, daifalla n, liu c, campos-neto a. alternative approach to express mycobacterium tuberculosis proteins in escherichia coli. biotechniques. 2003 jul;35(1):34-6, 38, 40.
dorothee brügger, klaus brischwein, charlie liu , peter bader, dietrich niethammer, volker gekeler and james f. beck. induction of drug resistance and protein kinase c genes in a2780 after incubation with antineoplastic agents at sublethal concentrations. anticancer res. 2002 nov-dec; 22(6c):4229-32.
c. liu , z-j xu, d. gupta, and r. dziarski. peptidoglycan-recognition protein: a novel family of four human innate immunity pattern recognition molecules. (cover page) j biol chem 2001 sep 14;276(37):34686-94
j. beck, d. brugger, k. brischwein, c liu , p. bader, d. niethammer , and v. gekeler. anticancer drug-mediated induction of multidrug resistance-associated genes and protein kinase c isozymes in the t-lymphoblastoid cell line ccrf-cem and in blasts from patients with acute lymphoblastic leukemias. jpn j cancer res 2001 aug;92(8):896-903
c. liu , e. gelius, g. liu, h. steiner, and r. dziarski. mammalian peptidoglycan-recognition protein binds peptidoglycan, is expressed in neutrophils, and inhibits bacterial growth.
j. biol. chem 2000, 275:22490-9
z-m. wang, c. liu , and r. dziarski. chemokines are the main pro-inflammatory mediators in human monocytes activated by staphylococcus aureus, peptidoglycan, and endotoxin. j. biol. chem. 2000, 275:20260-7
bader, f. schilling, m. schlaud, r. girgert, r. hangretinger, t. kinhgebiel, j. treuner, c. liu , d. niethammer, and j.f. beck. expression analysis of multidrug resistance associated genes in neuroblastomas. oncology reports, 1999, 6:1143-46
d. bruegger, h. herbart, v. gekeler, g. seitz, c. liu , t. lkingebiel, t. orlikowsky, h. einsele, c. denzlinger, p. bader, d. niethammer, j.f. beck. functional analysis of p-glycoprotein and multidrug resistance associated protein related multidrug resistance in aml-blasts. leukemia res. 1999, 23:467-475
j. beck, b. bohnet, d. brugger, p. bader, j. dietl, rj. scheper, r. kandolf, c. liu , d. niethammer, v. gekeler. multiple gene expression analysis reveals distinct differences between g2 and g3 stage breast cancers, and correlation of pkc with mdr1, mrp, and lrp gene expression. br. j. cancer 1998,77(1):87-91
charlie liu , etc. modulation of multidrug resistance gene(mdr-1) with antisense oligodeoxynucleotides. clinical science ( london ) 1996, 91:93-98
charlie liu , etc. establishment and identification of multidrug resistant k562/adr cell line. chin j cancer 1996,1:28-32
charlie liu , etc. initial study on g6pd and 6pgd activity in multidrug resistant k562/adr cell line. chin j hematol 1995,15(7):321-323
charlie liu , etc. the susceptibility of drug resistant leukemia cells to nk and lak cells. chin j hematol 1995,16(2):89-91
charlie liu , etc. a novel improved microcytotoxicity assay to detect t lymphocyte subsets and nk cells and their significance in acute leukemia. shanghai lab med j 1992,5:256-258
charlie liu , etc. nk cell and its prognostic implications in acute leukemia. shanghai med j 1992,15(5):259-265 简历编号:1927536
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